IBISC participe au Research Day 2019 du Labex DigiCosme – Paris Saclay, le lundi 3 juin 2019

Sergiu Ivanov représente le laboratoire IBISC dans le cadre du Research Day 2019 du Labex DigiCosme de l’Université Paris-Saclay, le lundi 3 juin 2019.

La thématique de la journée est « De la sécurité des réseaux, aux réseaux du futur en passant par l’intelligence artificielle ».

Présentation de Sergiu Ivanov

Titre: Sequential Reprogramming of Biological Network Fate

Résumé:

A major challenge in precision medicine consists in finding the appropriate network
rewiring to induce a particular reprogramming of the cell phenotype. The rewiring is
caused by specific network action either inhibiting or over-expressing targeted
molecules. In some cases, a therapy abides by a time-scheduled drug administration
protocol. Furthermore, some diseases are induced by a sequence of mutations leading
to a sequence of actions on molecules. In this paper, we extend previous works on
abductive-based inference of network reprogramming by investigating the sequential
control of Boolean networks. We present a novel theoretical framework and give an
upper bound on the size of control sequences as a function of the number of observed
variables. We also define an algorithm for inferring minimal parsimonious control
sequences allowing to reach a final state satisfying a particular phenotypic property